Beilstein J. Org. Chem.2022,18, 95–101, doi:10.3762/bjoc.18.10
chemoenzymatic method was found to be superior over the chemical method in respect of the number of synthetic steps and overall yield of the final product.
Keywords: bicyclic AZT analogues; bridged homoarabinofuranosylpyrimidine nucleosides; chemical pathway; Lipozyme® TL IM; regioselectiveenzymatic
acetylation; Introduction
In the last few decades, modification of nucleoside/nucleotide analogues has been a field of keen interest to researchers due to their therapeutic properties for treatment of cancer, viral and microbial infections [1][2][3][4][5][6][7][8][9]. The very first cytotoxic
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Graphical Abstract
Figure 1:
Structure of AZT and representative related bicyclic nucleosides.